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Custom DNA/RNA Oligos> | … described [9]. Briefly, at age eight weeks, mice were anesthetized with isoflurane and a sub- cutaneous injection was done at two dorsal sites containing a total of 200 μg myelin oligoden- drocyte glycoprotein (MOG) peptide (MOG 35–55; Genscript, Piscataway, NJ, USA) emulsi … | Get A Quote |
ST266 is the biological secretome of cultured Amnion-derived Multipotent Progenitor cells containing multiple growth factors and cytokines. While intranasally-administered ST266 improves the phenotype in experimental optic neuritis, specific ST266 components mediating these effects are not known. We compared the effects of ST266 with and without removal of large molecular weight proteins both in vitro and in the multiple sclerosis model experimental autoimmune encephalomyelitis (EAE) in C57BL/6J mice. Mice were treated daily with intranasal vehicle, ST266 or lower molecular weight fraction of ST266. Retinal ganglion cells were counted in isolated retinas, and optic nerves were assessed for inflammation and demy... More